Endocrine Abstracts

Background: Adiponectin and resistin belong to the group of adipocytokines, that are thought to be involved in regulation of insulin sensitivity, and that also exert the opposite effects on inflammatory processes related to atherosclerosis and cardiovascular risk. Glucocorticoids have anti-inflammatory properties, but also increase insulin resistance. There are, however, conflicting data on the effects of glucocorticoids on serum concentrations of adiponectin and resistin....

Background and aims: Mechanism underlying the IR (Insulin-resistance) remains yet to be identified. Resistin has been shown to antagonize insulin action, and thus might be implicated in the pathogenesis of IR. In contrast, adiponectin has been shown to increase insulin sensitivity and improve glucose tolerance. We aimed to test the hypothesis that resistin levels might correlate positively with the indices of insulin resistance, while the opposite might be true for adiponectin...

It is recognized that a substantial proportion of patients found to have raised prolactin (PRL) level on a single testing is subsequently found to have normal PRL levels. Though this is often attributed to stress or medication factor, it should be noted, that PRL secretion displays diurnal variation with a nocturnal peak in the late-night/early morning hours. In our study we tested the hypothesis, that in some patients raised PRL levels in the morning may reflect individual di...